László Poppe, Dr., Ph.D., C. Sc.




  • Office, Laboratory:
  • Ch. ép. I. em. 126. "Déli Labor"

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  • Mail Address:
  • Technical University of Budapest
  • Institute for Organic Chemistry
  • H-1111 Budapest, XI.
  • Szent Gellért tér 4.
  • HUNGARY

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  • Telephone: (36-1)-463-2229

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  • Fax: (36-1)-463-3297

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  • E-mail: poppe.szk@chem.bme.hu


  • Membership, Functions

    1. 1984- : Hungarian Chemical Society
    2. 1994- : Hungarian Biochemical Union
    3. 1992- : Hungarian Humboldt Union
    4. secretary, 1993- : Committee of Terpenoid Chemistry, Hungarian Academy of Sciences

    Background

  • 1983: graduated from Technical University Budapest (TUB), (chemical engineering, diploma in organic chemistry: synthesis of pheromones)
  • 1983-86: fellowship (Hungarian Academy of Sciences);by Prof. L. Novak Institute for Organic Chemistry, TUB ) Stereoselective synthesis of pheromones, Synthetic use of hydrolytic enyimes, Development of novel preparative chromatographic methods)
  • 1987: Ph.D (C.Sc) degree (Stereoselective Syntheses of Potential Plant Protecting Agents)
  • 1986-91: research fellow of (C.R.I.C.) at the Inst. Org. Chem., TUB: (Synthetic use of biocatalysts; Synthese of pheromones and other biologically active compounds)
  • 1991-92: fellowship (Alexander von Humboldt Foundation), Department of Biochemistry, University Karlsruhe Germany; by Prof. János Rétey (Mechanism of action of coenzyme-B12-dependent enzymes: synthesis and enzyme kinetic study of coenzyme-B12 analogues)
  • 1993-: senior research fellow of (C.R.I.C.) at the Inst. Org. Chem., TUB: (Synthetic biocatalysis: Mechanism of action of coenzyme-B12-dependent enzymes; Stereoselective syntheses)
  • 1996: Dr. Habil. degree, Faculty of Chemical Engineering, TUB


  • Research Interests

    Synthetic chemistry: stereoselective synthesis, use of biocatalysis
    Biochemistry: mechanistic study of enzyme action; development of biocatalytic methods
    Analytical and preparative separation techniques: use and development
    Computational techniques in the above areas

    Teaching

    (at TUB, in Hungarian):
  • Selective Biocatalysis: Synthetic Application (lecture)
  • Organic Chemistry III (seminars)
  • Computer Techniques III (use of chemistry related softwares)
  • Diploma, Ph.D. tutor

  • (at TUB, in English):
  • Organic Chemistry Practice I, Organic Chemistry Practice II (laboratory practice)


  • Selected Publications

    Monograph:

    Poppe, L., Novák, L.:Selective Biocatalysis: A Synthetic Approach, Weinheim-New York: Verlag Chemie, 1992.

    Papers:

    1.
    Poppe, L., Novák, L., Kolonits, P., Bata, Á., Szántay, Cs.: Convenient Synthetic Route to (+)-Faranal and (+)-13-Norfaranal; The Trail Pheromone of Pharaoh's Ant and Its Congener
    Tetrahedron, 1988, 44, 1477.

    2.
    Poppe, L., Hull, W.E., Rétey, J.: Synthesis and Characterization of (5'-Deoxyadenosin-5'-yl)cobalamin (='Adenosylcobalamin') Analogues Mimicking the Transition-State Geometry of Coenzyme-B12-Dependent Rearrangements
    Helv. Chim. Acta, 1993, 76, 2367.

    3.
    Poppe, L., Novák, L., Kajtár-Peredy, M., Szántay, Cs.: Lipase-Catalysed Enantiomer Selective Hydrolysis of 1,2-Diol Diacetates.
    Tetrahedron:Asymmetry, 1993, 4, 2211.

    4.
    Poppe, L., Rétey, J.: [w-(Adenosin-5'-O-yl)]cobalamins Mimicking the Posthomolysis Intermediate of Coenzyme B12-Dependent Rearrangements: Kinetic Investigations on Methylmalonyl-CoA Mutase
    Arch. Biochem. Biophys., 1995, 316, 541.

    5.
    Egri, G., Fogassy, E., Novák, L., Poppe, L.: Synthesis and Lipase-catalyzed Asymmetric Acetylation of 3-Hydroxy-2-hydroxymethylpropanal Acetals
    Tetrahedron:Asymmetry, 1997, 8, 547.

    6.
    Poppe, L., Rétey, J.: Kinetic Investigations using Inhibitors Mimicking the Posthomolysis Intermediate in the Coenzyme-B12 Dependent Glycerol Dehydratase and Diol Dehydratase Reactions
    Eur. J. Biochem., 1997, 245, 398.



     
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  • Last update: 08-12-97.